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doi: 10.1371/journal.pone.0288718 Summary Keywords GLP-1 receptor agonists, gut microbiome modulation, incretinmicrobiota axis, metabolism, therapeutic response variability Citation De La Motte LR, Carreras F and Drago L (2026) The gut microbiota as a potential determinant of response to GLP-1 receptor agonists: a narrative review

plasma concentrations of intact orlistat were near the limits of detection ( 99% bound to plasma proteins (lipoproteins and albumin were major binding proteins)